Describe the Mechanism of Action of Upadacitinib

Ingrid Pan, a pediatric clinical pharmacist at Children's Hospital Colorado, explains the mechanism of action of upadacitinib in this medication review video module. She describes how upadacitinib, a selective JAK1 inhibitor, functions within the immune pathway by inhibiting cytokine signaling and interferons. Ingrid highlights that while selective JAK1 inhibition aims to reduce the risk of cytopenias, clinical data has not fully supported this benefit compared to other JAK inhibitors that target JAK2, JAK3, and TYK2.