Describe The Mechanism of Action of Guselkumab

Join Danielle Gatti Palumbo, a clinical pharmacist at the Division of Rheumatology at Northwell Health in Long Island, New York, as she reviews the mechanism of action of guselkumab. Learn how guselkumab interacts with IL-23, a pro-inflammatory cytokine that activates T helper TH17 cells, leading to the production of IL-17 and other cytokines responsible for tissue and chronic inflammation seen in conditions like psoriatic arthritis, psoriasis, and IBD. Discover how IL-23 signaling in the skin, joints, and gut mucosa contributes to inflammation and disease progression.