Describe the IL23/IL17 Axis

Join Katie Springer, a Physician Assistant in Rheumatology at Northwestern Hospital in Lake Forest, Illinois, as she explains the IL-23/IL-17 axis. Katie dives into the structure and function of IL-23, a pro-inflammatory cytokine composed of two subunits, IL-23 and IL-12/23. She discusses how IL-23, secreted by activated macrophages and dendritic cells in tissues like the skin, intestinal mucosa, joints, and lungs, plays a crucial role in protecting against bacterial and fungal infections by inducing the differentiation and activation of T-helper type 17 (TH17) cells.