Describe the IL17-Induced Inflammatory Cascade

Join Robert Laugherty, PA-C, JD, a rheumatology specialist with over 16 years of experience, as he explores IL-17, a key cytokine involved in immune defense and chronic inflammatory diseases. IL-17 plays a critical role in host protection against extracellular bacteria and fungi, while its dysregulation contributes to autoimmune conditions such as psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis.

IL-17 is a family of six proteins (IL-17A to IL-17F) that function downstream of IL-23, activating epithelial cells, fibroblasts, and keratinocytes to release inflammatory cytokines and recruit neutrophils. This cascade amplifies immune responses through key signaling pathways, including NF-κB, MAPK, and C/EBP transcription factors. The persistent activation of IL-17-driven inflammation is a hallmark of several rheumatic diseases, making it a significant target for biologic therapies.

For rheumatology APPs, clinicians, and researchers, understanding the IL-17 pathway is essential for optimizing treatment strategies and advancing targeted therapies in autoimmune disease management.

For more expert insights and the latest advancements in rheumatology, download the RhAPP ACE App for valuable resources and clinical updates.