Define, Compare, and Contrast Humoral and Cell-Mediated Immunity

In this educational FAQ video, Katie Springer, PA-C, from Northwestern Medicine at Lake Forest Hospital, Illinois, provides a clear and concise breakdown of humoral and cell-mediated immunity—two essential components of the adaptive immune system.

Humoral immunity, driven by B cells and antibodies, plays a critical role in neutralizing extracellular pathogens, preventing infections, and building long-term immune memory. In contrast, cell-mediated immunity relies on T cells to target intracellular threats, including viruses and cancerous cells. Katie also explores how the IL-23/IL-17 pathway influences immune responses, contributing to autoimmune diseases such as psoriasis and inflammatory arthritis.

This discussion is particularly relevant for APPs and healthcare providers managing autoimmune and infectious diseases. A deeper understanding of these immune pathways enhances clinical decision-making, guiding targeted therapies and vaccine strategies.

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