Describe JAK-STAT signaling in inflammation

In this FAQ video module, Heather Mambretti, a physician assistant with over 12 years of experience in rheumatology, explains the JAK-STAT pathway and its role in the inflammatory process. She covers how this signaling pathway transduces cytokines, which are critical in the development of autoimmune diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, and inflammatory bowel disease. Heather breaks down how the JAK-STAT cascade activates gene transcription, contributing to the pathogenesis of these conditions.